EMBL Rome is changing. Last year we focussed our research on epigenetics and neurobiology, and as a consequence have recruited several new groups specialised in one or the other topic (e.g. see Boulard and Asari labs). Next up is a comprehensive site renovation to upgrade to a state-of-the-art campus, whilst further group leader recruitments are also in the pipeline. These are exciting times, and should remain so thanks to a new funding scheme that encourages research at the interface between epigenetics and neurobiology. This interdisciplinary funding bridges the two distinct themes at EMBL Rome and has already begun to foster cross-collaboration between groups. More broadly, the field of ‘neuroepigenetics’ is expanding rapidly and by leveraging the expertise of specialist labs on site, EMBL Rome could contribute key insights in the coming years.